Y'mean keyfarme? Or layer? Not quite getting you. More details. Also, if you haven't, run through the manual, especially the tutorials. It's got all the basics and then some, spelled out nice 'n clear. If you're still stumped, I'll check back.
if you want to make a keyframe, slide the timelines timebar over to where you want your anmation to land and move a point, or a group of points, or bones, or whatever.
But for future, please read the tutorials and help files included in Moho.