I'm doing a music video right now, hand-drawn animation in TVPaint, in HD (1280 x 720). Some scenes are just pans or multiplane work, but these lead to big files in TVP because there you store each layer in frame at full bitmap resolution - 10 sec easily cost me 500 MB. So I rendered some layers as PNGs, made the rain a QT loop, and imported everything in AS. Not only that setting up a multiplane pan is much faster here, the file is also a mere 12 k because it only contains references to the image files.
I will continue with this combination of software since I like that crayon look (which is done completely digitally ...) The video is expected to be finished in January.
Thx for the comments. I also should add some shadows, but leave that until I have the characters placed in that scene. Overall it's a bit too detailed for TV, but I hope to be able to show it in HD at festivals.
